Our Patent Pending Blend is Based on the Latest Scientific Studies and Emerging Research as Follows:
Scientists around the world have been investigating polyphenolic
compounds such as resveratroland have shown in
laboratory studies that these compounds can potentially improve health and
well-being.*1
Public health agencies such as the National Institutes of Health
(NIH), the National Cancer Institute (NCI), the National Institute on
Aging(NIA) as well as the United States Department of Agriculture (USDA) have
reviewed and studied the potential lifestyle benefits of phenolic
compounds.2
The National Institutes of Health (NIH) spent over $2.4
billion in 2007 alone to further the scientific understanding of the processes
of aging. Towards this end, the National Institute on Aging (NIA) has taken the
lead to further the understanding of aging and supports some of the laboratory
research on resveratrol and improved health.*3,2
A landmark laboratory study from Harvard Medical School and
published in Nature in 2006 suggests that resveratrol improves energy
balance and may protect against cellular aging processes in
mice.*4
Later this study data was converted into a human dose
equivalent and published by a research team in a 2007 online and 2008
print journal issue of the Federation of American Societies for Experimental
Biology (FASEB). 5,6
More recent studies published this year in PLoS
ONE, June 2008 and Cell Metabolism, August 2008 indirectly confirm
the potential positive effects and intake levels as
well.7,8
Specifically, researchers from the National Institute on Aging
and other institutions published in the 2008 issue of Cell
Metabolism data confirming that resveratrol may mimic, in laboratory
studies, almost all of the effects of dietary or calorie restriction. This
process may activate genetic regulators of cellular longevity pathways, which
may have positive effects on cellular health and metabolism.*8
Most importantly, the Linus Pauling Institute at Oregon State
University and other organizations explain that ‘resveratrol is
not known to be toxic or cause adverse effects in humans. Most prominently,
safety data from animal studies were published in Toxicoll Sciences in
2004 and in the Journal of Nutrition in 2002. Furthermore, a recent
trial that evaluated the safety of oral resveratrol in ten subjects found a
single dose from 0.5 to 5 grams resulted in no serious adverse effects. The
study was published in 2007 in Cancer Epidemiol Biomarkers
Prev.9.10,11,12
References:
PubMed, a service of the National Library of Medicine, located at the
National Institutes of Health, visit at http://www.ncbi.nlm.nih.gov/pubmed/.
U.S. Department of Health and Human Services, National Institutes of
Health: Estimates of funding for various diseases, conditions, research areas.
Table Updated February 2008.
Baur JA, Pearson KJ, Price NL, and Jamieson HA, Sinclair DA et al:
Resveratrol improves health and survival of mice on a high-calorie diet.
Nature 2006 Nov 16; 444(7117):337-42.
Reagan-Shaw S et al: Dose Translation from animal to human studies
revisited. The FASEB Journal published online before print as doi:
10.1096/fj.07-9574LSF, October 17, 2007.
Reagan-Shaw S et al: Dose translation from animal to human studies
revisited. The FASEB Journal 2008; 22:659-661.
Barger JL et al: A low dose of dietary resveratrol partially mimics caloric
restriction and retards aging parameters in mice. PLoS ONE, June 2008;
3, 6, 1-10.
Pearson K et al: Resveratrol delays age-related deterioration and mimics
transcriptional aspects of dietary restriction without extending life span.
Cell Metabolism, August 2008; 8, 1-12.
Juan ME, Vinardell MP, and Planas JM: The daily oral administration of high
doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr.
2002;132(2):257-260.
Boocock DJ, Faust GE, Patel KR, et al: Phase I dose escalation
pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer
chemopreventive agent. Cancer Epidemiol Biomarkers Prev.
2007;16(6):1246-1252.
Our Patent Pending Blend is Based on the Latest Scientific Studies and Emerging Research as Follows:
click here for Shaklee distribution of anti-aging supplements
